Symbol
Name
ID

Apc
APC, WNT signaling pathway regulator
MGI:88039

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Cerebellar hemorrhage	Abnormal bone marrow cell morphology	Hepatosplenomegaly
Disease(s) Associated with APC	Cerebellar hemorrhage	Abnormal bone marrow cell morphology	Hepatosplenomegaly
medulloblastoma
pancreatic cancer

Mouse Phenotypes

abnormal thymus morphology

abnormal Hassall's corpuscle morphology

small thymus

thymus hypoplasia

decreased thymocyte number

abnormal T cell differentiation

increased double-negative T cell number

arrested T cell differentiation

anemia

decreased hematocrit

increased mast cell number

decreased NK cell number

decreased NK T cell number

decreased T cell number

decreased macrophage cell number

abnormal effector T cell morphology

decreased splenocyte number

abnormal NK T cell physiology

Availability

Mouse Genotype

Apc^Min/Apc⁺

Apc^Min/Apc⁺
Tg(Rorc-EGFP)1Ebe/?

Apc^tm1.1Alew/Apc⁺

Apc^tm1.1Rsmi/Apc⁺

Apc^tm1.1Tno/Apc⁺

Apc^tm1.1Tyj/Apc⁺

Apc^tm1Cip/Apc⁺

Apc^tm2.1Alew/Apc⁺

Apc^tm2.1Rak/Apc⁺

Apc^tm1Kk/Apc^tm1Kk
Tg(Lck-cre)1Cwi/? (conditional)

Apc^tm2.1Cip/Apc^tm2.1Cip
Tg(Ttr-cre/Esr1*)1Vco/0 (conditional)

Apc^tm2Rak/Apc^tm2Rak
Tg(KRT14-cre)8Brn/0 (conditional)

Apc^tm2Rak/Apc^tm2Rak
Tg(Car1-cre)5Flt/0 (conditional)

Apc^tm1Tno/Apc⁺
Tg(CDX2-cre)101Erf/0 (conditional)

Apc^tm1Tno/Apc⁺
Tg(Vil1-cre)997Gum/0 (conditional)

Apc^tm2Rak/Apc⁺
Tg(Car1-cre)5Flt/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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